2025 Mercedes-Benz GLS vs. 2025 Infiniti QX80

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The 2025 Mercedes-Benz GLS and 2025 Infiniti QX80 bring different design languages and engineering priorities to the full-size SUV segment. Both offer three-row seating, strong engine performance, and luxury-focused features, but target different drivers. One prioritizes modern comfort, advanced technology, and refined ride quality. The other leans on bold styling, traditional V8 power, and a more truck-like feel. This head-to-head comparison shows how each vehicle performs across key categories like design, technology, and on-road behavior.

Design & Style

The 2025 GLS has a modern, balanced exterior that blends sleek curves and muscular proportions. The LED headlamps, sculpted side panels, and flush details create a clean and upscale presence. Inside, the cabin features high-end finishes with open-pore wood, brushed aluminum, and premium leather. The layout supports comfort and space without clutter. In contrast, the 2025 Infiniti QX80 adopts a bold, vertical grille and squared body shape. Its new design refreshes the aging platform but sticks with its traditional SUV cues. The interior feels large and commanding, but the dashboard layout and materials don’t match the same level of refinement. While both SUVs feel spacious, the GLS delivers a more modern and polished experience inside and out.

Technology & Safety

Inside the GLS, twin 12.3-inch digital displays provide a fully connected user experience. The MBUX infotainment system supports voice commands, biometric login, wireless smartphone integration, and augmented reality navigation. Safety technology includes active lane keeping, blind-spot assistance, adaptive cruise control, and traffic sign recognition. The QX80 offers a new 24-inch widescreen interface that houses gauge and infotainment functions. It includes Apple CarPlay, Android Auto, and some driver-assist systems, but advanced features like hands-free highway driving require upper trims. The QX80 brings noticeable improvements over its predecessor, but the GLS delivers smoother operation and more customizable tech right from the start.

Performance

The GLS 450 uses a turbocharged inline-six engine with EQ Boost mild-hybrid support. It produces confident acceleration, smooth gear changes, and quick torque delivery without unnecessary engine noise. The 4MATIC® all-wheel-drive system responds instantly to changes in traction, while adaptive air suspension keeps the ride level and composed. The QX80 still uses a naturally aspirated V8 engine, which provides high horsepower and torque but at the cost of fuel efficiency and engine refinement. Its rear-wheel-drive-based platform feels heavier in turns, and the body-on-frame layout affects overall ride smoothness. The GLS offers better balance, sharper handling, and quieter cruising across different driving conditions.

The Bottom Line

The 2025 Infiniti QX80 introduces updates that help it stay competitive, including a bold new design and a larger digital interface. It still appeals to drivers who want traditional SUV power with a strong presence. The 2025 GLS continues to lead with a smooth ride, modern interior, advanced tech, and confident driving behavior. It meets the needs of buyers looking for luxury that doesn’t compromise comfort or performance. While both vehicles provide three rows of space and capable engines, one delivers a more refined and feature-rich experience that suits everyday driving and long-distance travel.

Schedule a Test Drive Today

Explore the full-size luxury SUV that blends technology, comfort, and performance. Schedule a test drive at Mercedes-Benz of Smithtown to experience the 2025 GLS firsthand.

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